Glycosylated haemoglobin in chronic renal failure.

He remained well until he was admitted in February 1978 with a one-week history of fever, myalgia, and productive cough. After persistent questioning he admitted taking co-trimoxazole. Investigations showed blood urea concentration 18-6 mmol/l (112 mg/100 ml); serum creatinine concentration 390 Mmol/l (4-25 mg/l00 ml); urine output 28 ml/h; urine osmolality 330 mosmol/kg. After biopsy peritoneal dialysis was started and methyl prednisolone 1 g given intravenously for two days and then 0 5 g for another two days. Recovery was rapid. Creatinine clearance was 70 ml/min on discharge. Two months later intravenous urography showed normal-sized kidneys and biopsy showed only a few foci of lymphocytes and mild patchy interstitial fibrosis. On each occasion immunoglobulins, complement, antistreptolysin 0 titre, DNA binding, and eosinophil count were normal.